The Mendoza lab is located in the Department of Immunology and Microbiology at The Scripps Research Institute in La Jolla, California. The lab is primarily interested in the heterogeneity of cell populations inhabiting barrier tissues and how their interactions maintain the balance of responses against noxious insults and tolerance to benign stimuli. There are summaries of recent publications from the Mendoza lab, covering topics such as the transcriptional connectivity of regulatory T cells in the tumor microenvironment, the temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection, the assembly of a spatial circuit of T-bet-expressing T and B lymphocytes required for antiviral humoral immunity, the transcriptional basis of dendritic cell heterogeneity, the functional maturation of regulatory T cells that survey skin and vascular tissues, the stability and function of regulatory T cells expressing the transcription factor T-bet, the role of lymphatic endothelial S1P in promoting mitochondrial function and survival in naive T cells, and the regulation of natural killer cell function by S1P gradients in lymph nodes. These studies have investigated mechanisms of immune cell function regulation, such as lipid phosphatases and S1P transporters, providing new insights into the control of immune responses.
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- Located in: Scripps Research
- Address: 10550 N Torrey Pines Rd, La Jolla, CA 92037, United States
- Phone: +1 858-784-9644
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